Yes.  All incoming messages – except messages from domains and email addresses on your white-list – are scanned by Spam Assassin. White-listed address – as opposed to black-listed ones – are assumed to always be legitimate, as they have to be entered manually into the white-list and therefore must be legitimate.

 

Note: E-mail addresses belonging to your own domain are automatically white-listed, and are not therefore scanned by Spam Assassin.